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Selective Carbon-Carbon Bond Activation: A Wellspring of Untapped Reactivity




Project acronym: CMETC

ERC Publications


14) A unique Pd-catalysed Heck arylation as a remote trigger for cyclopropane selective ring-opening

Sukhdev Singh, Jeffrey Bruffaerts, Alexandre Vasseur, Ilan Marek

Nat. Commun., 2017, 8, 14200


13) Zirconocene catalyzed diastereoselective carbometalation of cyclobutenes

Sudipta Raha Roy, Hendrik Eijsberg, Jeffrey Bruffaerts and Ilan Marek

Chem. Sci., 2017,8, 334-339


12) Copper mediated carbometalation reactions

D. S. Müller and I. Marek

Chem.Soc. Rev., 2016,45, 4552-4566


11) Enantiodivergent Combined Carbometalation − Zinc Homologation – C-C Fragmentation Reaction as an Efficient Tool to Prepare Acyclic Allylic Quaternary Carbon Stereocenters

Sudipta Raha Roy , Dorian Didier , Amir Kleiner and Ilan Marek

Chem. Sci., 2016, 7, 5989–5994.


10) Formation of Carbon Quaternary Stereogenic Center in Acyclic Systems via a Sequence of Carbometalation − Intramolecular Cyclization − Silicon Activation

Maya Preshel-Zlatsin, Fa-Guang Zhang, Guillaume Eppe, Ilan Marek

Synthesis 2016, 48(19), 3279-3286


9) Preparation and Reactivity of Acyclic Chiral Allylzinc Species by a Zinc-Brook Rearrangement

Markus Leibeling, Khriesto A. Shurrush, Veronika Werner, Lionel Perrin, and Ilan Marek

Angew.Chem. Int.Ed. 2016, 55, 6057–6061


8) Stereoselective Formation of Fully Substituted Ketone Enolates

Elvira Haimov, Zackaria Nairoukh, Alexander Shterenberg, Tiran Berkovitz, Timothy F. Jamison, and Ilan Marek*

Angew. Chem. Int. Ed. 2016, 55, 5517 –5520


7) Remote functionalization through alkene isomerization

Alexandre Vasseur, Jeffrey Bruffaerts and Ilan Marek

Nature Chemistry, 2016, 8, 209–219


6) Asymmetric Copper-Catalyzed Carbozincation of Cyclopropenes en Route to the Formation of Diastereo- and Enantiomerically Enriched Polysubstituted Cyclopropanes

Daniel S. Müller and Ilan Marek

J. Am. Chem. Soc., 2015, 137 (49), 15414-15417


5) Stereodefined Acyclic Polysubstituted Silyl Ketene Aminals: Asymmetric Formation of Aldol Products with Quaternary Carbon Stereocenters

Zackaria Nairoukh and Ilan Marek

Angew. Chem. Int. Ed., 2015, 54, 14933-14937


4) Remote functionalization of hydrocarbons with reversibility enhanced stereocontrol.

Alexandre Vasseur, Lionel Perrin, Odile Eisenstein* and Ilan Marek*

Chem. Sci., 2015,6, 2770 - 2776


3) Selective Carbon–Carbon Bond Cleavage for the Stereoselective Synthesis of Acyclic Systems

Prof. Dr. Ilan Marek*, Dr. Ahmad Masarwa, Dr. Pierre-Olivier Delaye and Dr. Markus Leibeling

Angew. Chem. Int. Ed. 2015, 54, 414 – 429


2) Stereodefined acyclic trisubstituted metal enolates towards the asymmetric formation of quaternary carbon stereocentres

Yury Minko and Ilan Marek

Chem. Commun., 2014,50, 12597-12611


1) Merging Allylic C-H Activation and Selective C-C Bond Activation

Ahmad Masarwa, Dorian Didier, Tamar Zabrodsky, Marvin Schinkel, Lutz Ackermann and Ilan Marek*
Nature 2014, 505, 199-203

Highlighted in C&EN, 2013, December 16

Highlighted in Nature Chemistry, 2014, 6, 86